Deregulation of genetic pathways in neuroendocrine tumors
نویسندگان
چکیده
منابع مشابه
Deregulation of Wnt/β-catenin signaling through genetic or epigenetic alterations in human neuroendocrine tumors.
Carcinoid tumors are rare neuroendocrine tumors (NETs) that are increasing in incidence. Mutation and altered expression of Wnt/β-catenin signaling components have been described in many tumors but have not been well-studied in NETs. Here, we observed accumulation of β-catenin in the cytoplasm and/or nucleus in 25% of clinical NET tissues. By mutational analysis, the mutations of β-catenin (I35...
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Types of glioma brain tumors and genetic alterations in signaling pathways in them Background & Objective: Glioma is a common type of primary brain tumor originating in the glial cells that surrounds and supports neurons in the brain. These tumors arise from three different types of cells that are normally found in the brain: astrocytes, oligodendrocytes, and ependymal cells, accordingly types ...
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Barazeghi, E. 2017. Studies of epigenetic deregulation in parathyroid tumors and small intestinal neuroendocrine tumors. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1377. 53 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0097-9. Deregulation of the epigenome is associated with the initiation and progression of various types of human cancer...
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Neuroendocrine tumors (NETs) constitute a heterogeneous group of neoplasms including carcinoids, pancreatic neuroendocrine tumors, pituitary tumors, medullary thyroid carcinoma and phaeochromocytomas. The symptoms and the outcome of NETs differ considerably between patients depending on several factors. By labelling tracers with a radioisotope, the tracer acts as a ...
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Gastroenteropancreatic neuroendocrine tumors are relatively rare neoplasms but their incidence has significantly increased in the last 30 years. These tumors are usually sporadic but can also occur as part of certain endocrine tumor susceptibility syndromes such as multiple endocrine neoplasia type1 (MEN1) and von Hippel Lindau disease. The genetic abnormalities associated with the development ...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/37856